| Regular Season | Playoffs | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Season | Team | Lge | GP | G | A | Pts | PIM | +/- | GP | G | A | Pts | PIM | |
| 2009-10 | U.S. National Under-18 Team | USHL | 1 | 0 | 0 | 0 | 2 | -1 | -- | -- | -- | -- | -- | |
| 2009-10 | U.S. National Under-17 Team | USHL | 34 | 0 | 5 | 5 | 32 | -9 | -- | -- | -- | -- | -- | |
| 2010-11 | U.S. National Development Team | USHL | 19 | 2 | 4 | 6 | 4 | 6 | -- | -- | -- | -- | -- | |
| 2011-12 | U. of Wisconsin | WCHA | 26 | 3 | 9 | 12 | 12 | |||||||
| 2012-13 | U. of Wisconsin | WCHA | 38 | 3 | 18 | 21 | 50 | |||||||
| 2013-14 | U. of Wisconsin | Big-10 | 36 | 8 | 17 | 25 | 53 | |||||||
| 2013-14 | Buffalo Sabres | NHL | 7 | 0 | 1 | 1 | 15 | -3 | -- | -- | -- | -- | -- | |
| 2014-15 | Rochester Americans | AHL | 57 | 5 | 24 | 29 | 50 | -3 | -- | -- | -- | -- | -- | |
| 2014-15 | Buffalo Sabres | NHL | 2 | 0 | 0 | 0 | 0 | 0 | -- | -- | -- | -- | -- | |
| 2015-16 | Buffalo Sabres | NHL | 77 | 4 | 10 | 14 | 51 | 6 | -- | -- | -- | -- | -- | |
| 2015-16 | Rochester Americans | AHL | 1 | 0 | 0 | 0 | 0 | 0 | -- | -- | -- | -- | -- | |
| 2016-17 | Buffalo Sabres | NHL | 76 | 3 | 17 | 20 | 26 | -7 | -- | -- | -- | -- | -- | |
| 2017-18 | Buffalo Sabres | NHL | 53 | 3 | 9 | 12 | 26 | -11 | -- | -- | -- | -- | -- | |
| 2018-19 | Buffalo Sabres | NHL | 59 | 4 | 10 | 14 | 35 | -4 | -- | -- | -- | -- | -- | |
| 2019-20 | Buffalo Sabres | NHL | 66 | 3 | 10 | 13 | 41 | -11 | -- | -- | -- | -- | -- | |
| 2020-21 | Buffalo Sabres | NHL | 13 | 1 | 2 | 3 | 9 | 2 | -- | -- | -- | -- | -- | |
| 2021-22 | Chicago Blackhawks | NHL | 75 | 4 | 18 | 22 | 33 | -27 | -- | -- | -- | -- | -- | |
| 2022-23 | Chicago Blackhawks | NHL | 55 | 2 | 18 | 20 | 27 | 7 | -- | -- | -- | -- | -- | |
| 2022-23 | Toronto Maple Leafs | NHL | 21 | 1 | 4 | 5 | 29 | 12 | 11 | 0 | 2 | 2 | 10 | |
| 2023-24 | Toronto Maple Leafs | NHL | 73 | 8 | 20 | 28 | 56 | 20 | ||||||
| NHL Totals | 577 | 33 | 119 | 152 | 348 | 11 | 0 | 2 | 2 | 10 | ||||
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| Year | Tournament | Team | GP | G | A | Pts | PIM | +/- | |
| 2013 | World Junior U-20 Championships | USA U-20 | 7 | 3 | 3 | 6 | 16 | 9 | |
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